mouse monoclonal IgG2b; MAP LC3β Antibody (G-2) is an IgG2b κ mouse monoclonal MAP LC3β antibody (also designated MAP LC3β antibody or MAP LC3 antibody) that detects MAP LC3β and MAP LC3β2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. MAP LC3β Antibody (G-2) is available as the non-conjugated anti-MAP LC3β antibody form, as well as multiple conjugated forms of anti-MAP LC3β antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3β) and MAP-light chain 3 alpha (MAP-LC3α) are subunits of both MAP1A and MAP1B. MAP-LC3β, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3β, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3β, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3′ untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3β may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.