AP-1 Sumoylation site Antibody Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3725
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: JUN
Other Names: Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN
Availability: 2 weeks
Bio Background: The gene for AP-1 is the putative transforming gene of avian sarcoma virus 17. AP-1 is highly similar to the viral protein, and interacts directly with specific target DNA sequences to regulate gene expression. The AP-1 gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. AP-1 dimer activity is downregulated by SUMO-1, SUMO-2, and SUMO-3.
Bio References: Bossis, et al., Mol Cell Biol. 2005 Aug;25(16):6964-79.Perez-Sala, D., et al., J. Biol. Chem. 278(51):51251-51260 (2003).Yang, H., et al., J. Biol. Chem. 278(51):50887-50896 (2003).Toborek, M., et al., J. Neurochem. 84(1):169-179 (2003).Wang, Y.N., et al., J. Biol. Chem. 278(46):45848-45857 (2003).
Primary Accession: P05412
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2507b is HPRLQALKEEPQTVPE, containing a predicted sumoylation site from the C-terminal region of human AP-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.