Cynomolgus Integrin isoform alpha-7X1B beta 1 (ITGA7X1B&ITGB1) Heterodimer Protein, Tag Free&His Tag (MALS verified)

DESCRIPTION

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

DETAILS

Tag: Native | C-10×His
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
Format: Powder
Purity: 95%
Source: Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (IT1-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Pro 1081 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1) (Accession # XP_005571182.1 (ITGA7X1B) & XP_015311227.1 (ITGB1)).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Integrin isoform alpha-7X1B beta 1
Accession: XP_005571182.1 (ITGA7X1B) & A0A2K5WHU8-1 (ITGB1)
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Phe 34 - Pro 1081 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1)
Swiss-prot: A0A2K5UN90-1 (ITGA7X1B) & A0A2K5WHU8-1 (ITGB1)
Package Size: 1mg*1
Characteristics: Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag, produced by co-expression of ITGA7X1B and ITGB1, has a calculated MW of 115.1 kDa (ITGA7X1B) and 85.0 kDa (ITGB1). Subunit ITGA7X1B contains no tag but an acidic tail at the C-terminus and subunit ITGB1 contains a polyhistidine tag and a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 95-115 kDa due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 115.1 kDa (ITGA7X1B) & 85.0 kDa (ITGB1)
Shipping Condition: RT
Species Reactivity: Cynomolgus
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