LYK5 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 92335
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: STRADA
Other Names: STE20-related kinase adapter protein alpha, STRAD alpha, STE20-related adapter protein, Serologically defined breast cancer antigen NY-BR-96, STRADA, LYK5 {ECO:0000312|EMBL:AAP422801}, STRAD
Availability: 2 weeks
Bio Background: LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
Bio References: Baas, A.F., et al., EMBO J. 22(12):3062-3072 (2003).Scanlan, M.J., et al., (er) Cancer Immun. 1, 4 (2001) (): ().
Primary Accession: Q7RTN6
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7142a was selected from the N-term region of human LYK5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.