ACCN1 Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 40
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ASIC2
Other Names: Acid-sensing ion channel 2, ASIC2, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive cation channel neuronal 1, Brain sodium channel 1, BNC1, BNaC1, Mammalian degenerin homolog, ASIC2, ACCN, ACCN1, BNAC1, MDEG
Availability: 2 weeks
Bio Background: ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
Bio References: Bashari,E., et.al., Am. J. Physiol., Cell Physiol. 296 (2), C372-C384 (2009)Chai,S., et.al., J. Biol. Chem. 282 (31), 22668-22677 (2007)
Primary Accession: Q16515
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP9213c was selected from the Center region of human ACCN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.