HK3 (Hexokinase III) Antibody (N-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3101
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: HK3
Other Names: Hexokinase-3, Hexokinase type III, HK III, HK3
Availability: 2 weeks
Bio Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
Bio References: Furuta, H., et al., Genomics 36(1):206-209 (1996).Palma, F., et al., Mol. Cell. Biochem. 155(1):23-29 (1996).Colosimo, A., et al., Cytogenet. Cell Genet. 74(3):187-188 (1996).
Primary Accession: P52790
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP8139a was selected from the N-term region of human HK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.