mouse monoclonal IgG1; kleisin β Antibody (B-1) is an IgG1 κ mouse monoclonal kleisin beta antibody (also designated kleisin β antibody) that detects the kleisin beta protein of mouse, rat and human origin by WB, IP, IF and ELISA. kleisin β Antibody (B-1) is available as both the non-conjugated anti-kleisin beta antibody form, as well as multiple conjugated forms of anti-kleisin beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Chromosome formation and subsequent function require the activity of two condensin complexes, namely condensin I and condensin II, both of which are crucial for proper mitotic chromosome assembly and segregation. Kleisin β, also known as NCAPH2 (non-SMC condensin II complex, subunit H2) or CAPH2, is a 605 amino acid protein that localizes to the nucleus and is specifically distributed along the arms of assembled chromosomes. Existing as a component of the condensin II complex, kleisin β functions as a regulatory protein that assists in establishing mitotic chromosome architecture, possibly by providing an increased level of organization and rigidity to formed chromosomes. In response to DNA damage, kleisin β is subject to phosphorylation by ATM or ATR. Multiple isoforms of kleisin β exist due to alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.