CFH Antibody (Center) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3075
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CFH
Other Names: Complement factor H, H factor 1, CFH, HF, HF1, HF2
Availability: 2 weeks
Bio Background: This gene is a member of the Regulator of ComplementActivation (RCA) gene cluster and encodes a protein with twentyshort concensus repeat (SCR) domains. This protein is secreted intothe bloodstream and has an essential role in the regulation ofcomplement activation, restricting this innate defense mechanism tomicrobial infections. Mutations in this gene have been associatedwith hemolytic-uremic syndrome (HUS) and chronic hypocomplementemicnephropathy. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized.
Bio References: Dieterich, R., et al. Infect. Immun. 78(11):4467-4476(2010)Sofat, R., et al. Atherosclerosis 213(1):184-190(2010)Davila, S., et al. Nat. Genet. 42(9):772-776(2010)Scambi, C., et al. PLoS ONE 5 (8), E12162 (2010) :Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)
Primary Accession: P08603