VEGFR-3 (FLT4) Antibody (C-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 2324
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: FLT4
Other Names: Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4, FLT4, VEGFR3
Availability: 2 weeks
Bio Background: FLT4, a member of the CSF-1/PDGF receptor subfamily of Tyr protein kinases, is a receptor for VEGFC. This Type I membrane protein is expressed in placenta, lung, heart, and kidney, but does not seem to be expressed in pancreas and brain. Defects in FLT4 are the cause of hereditary lymphedema I, also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Hereditary lymphedema I shows autosomal dominant inheritance and is characterized by onset usually at birth. Defects in FLT4 are also found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10/% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
Bio References: Walter, J.W., et al., Genes Chromosomes Cancer 33(3):295-303 (2002).Karkkainen, M.J., et al., Nat. Genet. 25(2):153-159 (2000).Irrthum, A., et al., Am. J. Hum. Genet. 67(2):295-301 (2000).Ferrell, R.E., et al., Hum. Mol. Genet. 7(13):2073-2078 (1998).Galland, F., et al., Oncogene 8(5):1233-1240 (1993).
Primary Accession: P35916
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7645b was selected from the C-term region of human FLT4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.