ALK Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 238
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ALK
Other Names: ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Availability: 2 weeks
Bio Background: ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2;5)(p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Bio References: Morris, S.W., et al., Oncogene 14(18):2175-2188 (1997).Iwahara, T., et al., Oncogene 14(4):439-449 (1997).Morris, S.W., et al., Science 263(5151):1281-1284 (1994).Morris, S.W., et al., Oncogene 15, 2883-2883 (1997).
Primary Accession: Q9UM73
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7600c was selected from the Center region of human ALK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.