79775
Scientist.com Supplier
HPK1 Assay Kit
BPS Bioscience
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DESCRIPTION:
The HPK1 Assay Kit is designed to measure HPK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
DETAILS
- Shiptemp: -80°C (dry ice)
- Synonyms: MAP4K1, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, Hematopoietic Progenitor Kinase 1, MAPK/ERK Kinase Kinase Kinase 1
- Warnings: Avoid freeze/thaw cycles.
- Category: Kinase/Assay Kit
- Background: HPK1 (MAP4K1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. It is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76, suggesting HPK1 could be a novel target for anti-tumor immunotherapy.
- References: 1. Wu P, et al., Structure, 2019, 27: 125-133.e42. Alzabin S, et al., J. Immunol. 2009, 182: 6187-61943. Jakob SM, et al., Blood, 2013, 121(20):4184-4194
- Description: The HPK1 Assay Kit is designed to measure HPK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
- Methodology: Chemiluminescent
- Supplied As: The HPK1 Assay Kit comes in a convenient 96-well format, with enough purified recombinant HPK1 enzyme, HPK1 substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
- Unspsc Code: 41105332
- Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
- Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
- Product Type: Assay Kit
- Biosafety Level: Not applicable (BSL-1)
- Related Products: 40126, 40107, 40398, 79686, 78487
- Storage Stability: Up to 6 months when stored as recommended
- Scientific Category: Kinase