SLIT1 Antibody (N-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 6585
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SLIT1
Other Names: Slit homolog 1 protein, Slit-1, Multiple epidermal growth factor-like domains protein 4, Multiple EGF-like domains protein 4, SLIT1, KIAA0813, MEGF4, SLIL1
Availability: 2 weeks
Bio Background: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
Bio References: Marlow, R., et al. Cancer Res. 68(19):7819-7827(2008)Hussain, S.A., et al. J. Biol. Chem. 281(51):39693-39698(2006)Lin, L., et al. Stem Cells 24(11):2504-2513(2006)Lim, J., et al. Cell 125(4):801-814(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Primary Accession: O75093
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP13374a was selected from the N-term region of SLIT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.