Yeast SUMO Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 852122
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SMT3
Other Names: Ubiquitin-like protein SMT3, SMT3
Availability: 2 weeks
Bio Background: Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. In yeast this protein has been shown to regulate chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics.
Bio References: Muller S, et al., Nat Rev Mol Cell Biol. 2001 2(3):202-10 Review.Hochstrasser M. Cell. 2001 107(1):5-8. Review.Kahyo T, et al., Mol Cell. 2001 Sep;8(3):713-8.Yeh ET, et al., Gene. 2000 May 2;248(1-2):1-14. Review.Keane,M.M., et al., Oncogene 18 (22), 3365-3375 (1999)
Primary Accession: Q12306
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1289a was selected from the N-term region of human Yeast SUMO . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.