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FZ4-H5250-100ug FZ4-H5250-1mg

Human Frizzled-4 / FZD4 Protein, Fc Tag

ACROBiosystems

DETAILS

  • Tag: C-Fc
  • Host: HEK293
  • Size: 1mg
  • Buffer: PBS, pH7.4
  • Format: Powder
  • Purity: 95%
  • Storage: -20℃
  • Category: Bio-Markers & CD Antigens
  • Molecule: Frizzled-4
  • Accession: AAI14528
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).
  • Exp Region: Phe 37 - Glu 180
  • Swiss-prot: Q9ULV1
  • Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 42.9 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html

DESCRIPTION

Human Frizzled-4, Fc Tag (FZ4-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 37 - Glu 180 (Accession # AAI14528).