Mouse Alpha-Synuclein Protein, His Tag (MALS verified)

DESCRIPTION

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

DETAILS

Tag: C-10×His
Host: E. coli
Size: 200ug
Buffer: 100 mM NaAC, pH7.0
Format: Powder
Purity: 95%
Source: Mouse Alpha-Synuclein, His Tag (ALN-M52H6) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # O55042-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: Alpha-synuclein
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 1 - Ala 140
Swiss-prot: O55042-1
Package Size: 200ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 16.4 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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