BCL10 Antibody (N-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 8915
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: BCL10
Other Names: B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP
Availability: 2 weeks
Bio Background: This gene was identified by its translocation in a case ofmucosa-associated lymphoid tissue (MALT) lymphoma. The proteinencoded by this gene contains a caspase recruitment domain (CARD),and has been shown to induce apoptosis and to activate NF-kappaB.This protein is reported to interact with other CARD domaincontaining proteins including CARD9, 10, 11 and 14, which arethought to function as upstream regulators in NF-kappaB signaling.This protein is found to form a complex with MALT1, a proteinencoded by another gene known to be translocated in MALT lymphoma.MALT1 and this protein are thought to synergize in the activationof NF-kappaB, and the deregulation of either of them may contributeto the same pathogenetic process that leads to the malignancy.
Bio References: Bhattacharyya, S., et al. Exp. Cell Res. 316(19):3317-3327(2010)Edin, S., et al. Mol. Immunol. 47 (11-12), 2057-2064 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Bhattacharyya, S., et al. J. Biol. Chem. 285(1):522-530(2010)Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)
Primary Accession: O95999