Phospho-EP300(S89) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 2033
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: EP300
Other Names: Histone acetyltransferase p300, p300 HAT, E1A-associated protein p300, EP300, P300
Availability: 2 weeks
Bio Background: EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
Bio References: Finlan, L., et al., J. Biol. Chem. 279(47):49395-49405 (2004).Dornan, D., et al., Mol. Cell. Biol. 24(22):10083-10098 (2004).Jin, Y.H., et al., J. Biol. Chem. 279(28):29409-29417 (2004).Kung, A.L., et al., Cancer Cell 6(1):33-43 (2004).Chen, J., et al., Cell. Mol. Life Sci. 61(13):1675-1683 (2004).
Primary Accession: Q09472
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3197a was selected from the region of human Phospho-EP300-S89. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.