Anti-Mesothelin (Mesothelial Marker) Monoclonal Antibody (Clone: MSLN/2131)

DESCRIPTION

Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.

DETAILS

Gene: MSLN
App Id: IHC
Gene Id: 10232
Isotype: Mouse IgG2b, kappa
Clone Name: MSLN/2131
Uniprot Id: Q13421
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human, Mouse, Rat
Product Content: 200µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: CAK1; Megakaryocyte potentiating factor; Mesothelin; MSLN; SMR; SMRP
Application Note: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes);
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
Immunogen Information: Recombinant fragment (around aa 273-407) of human Mesothelin (MSLN) protein (exact sequence is proprietary)