DAAM1 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 23002
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: DAAM1
Other Names: Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666
Availability: 2 weeks
Bio Background: Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton. Recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.
Bio References: Liu,W., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 210-215 (2008)Yamashita,M.,Genes Cells 12 (11), 1255-1265 (2007)Lu,J., J. Mol. Biol. 369 (5), 1258-1269 (2007)
Primary Accession: Q9Y4D1
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2720a was selected from the N-term region of humanAM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.