PARP1 Antibody (Center S782) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 142
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PARP1
Other Names: Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
Availability: 2 weeks
Bio Background: This gene encodes a chromatin-associated enzyme,poly(ADP-ribosyl)transferase, which modifies various nuclearproteins by poly(ADP-ribosyl)ation. The modification is dependenton DNA and is involved in the regulation of various importantcellular processes such as differentiation, proliferation, andtumor transformation and also in the regulation of the molecularevents involved in the recovery of cell from DNA damage. Inaddition, this enzyme may be the site of mutation in Fanconianemia, and may participate in the pathophysiology of type Idiabetes.
Bio References: Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)Kim, M., et al. Cancer Sci. 101(11):2436-2442(2010)Dong, Y., et al. Cancer Res. 70(20):8088-8096(2010)Krishnakumar, R., et al. Mol. Cell 39(5):736-749(2010)Lee, K.A., et al. Rheumatol. Int. (2010) In press :
Primary Accession: P09874