PDGFRA Antibody (Y768) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5156
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PDGFRA
Other Names: Platelet-derived growth factor receptor alpha, PDGF-R-alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2, CD140a, PDGFRA, PDGFR2, RHEPDGFRA
Availability: 2 weeks
Bio Background: PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Bio References: Wilczynski, S.P., et al., Hum. Pathol. 36(3):242-249 (2005).Hiwatari, M., et al., Leukemia 19(3):476-477 (2005).Debiec-Rychter, M., et al., Gastroenterology 128(2):270-279 (2005).Sakurai, S., et al., Hum. Pathol. 35(10):1223-1230 (2004).Subramanian, S., et al., Oncogene 23(47):7780-7790 (2004).
Other Accession: NP_006197
Primary Accession: P16234
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7666h was selected from the Y768 region of human PDGFRA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.