mouse monoclonal IgG1; MCT1 Antibody (H-1) is an IgG1 κ mouse monoclonal MCT1 antibody (also designated Monocarboxylate transporter 1 antibody, or SLC16A1 antibody) that detects the MCT1 protein of human origin by WB, IP, IF, IHC(P) and ELISA. MCT1 Antibody (H-1) is available as both the non-conjugated anti-MCT1 antibody form, as well as multiple conjugated forms of anti-MCT1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate.The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCT in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.