CPT1A Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 1374
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CPT1A
Other Names: Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1
Availability: 2 weeks
Bio Background: The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.
Bio References: Rasmussen, B.B., et al., J. Clin. Invest. 110(11):1687-1693 (2002).Ogawa, E., et al., J. Hum. Genet. 47(7):342-347 (2002).Cook, G.A., et al., Am. J. Med. Sci. 318(1):43-48 (1999).IJlst, L., et al., J. Clin. Invest. 102(3):527-531 (1998).Britton, C.H., et al., Genomics 40(1):209-211 (1997).
Primary Accession: P50416
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2524b was selected from the C-term region of human CPT1A . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.