79603
Scientist.com Supplier
CDK7 Assay Kit
BPS Bioscience
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DESCRIPTION:
Cyclin-dependent kinase 7 (CDK7) assembled with Cyclin H and MAT1 comprises an important sub-component of the transcription factor TFIIH. It is known to have dual roles, which include transcription regulation via phosphorylating the C-terminal domain (CTD) of RNA polymerase II as well as controlling cell cycle progression as a CDK activating kinase (CAK). The CDK7 Assay Kit is designed to measure CDK7/Cyclin H/MAT1 activity for screening and profiling applications, using ADP-Glo® as a detection reagent.
DETAILS
- Uniprot: Q24216
- Shiptemp: -80°C (dry ice)
- Synonyms: Cyclin-dependent kinase 7, cyclin dependent kinase 7, CDK7, CDK-7.
- Warnings: Avoid freeze/thaw cycles.
- Category: Kinase/Assay Kit
- References: Uzma A. et al., Nature Review Drug Discovery 14:130-146 (2015)
- Description: Cyclin-dependent kinase 7 (CDK7) assembled with Cyclin H and MAT1 comprises an important sub-component of the transcription factor TFIIH. It is known to have dual roles, which include transcription regulation via phosphorylating the C-terminal domain (CTD) of RNA polymerase II as well as controlling cell cycle progression as a CDK activating kinase (CAK). The CDK7 Assay Kit is designed to measure CDK7/Cyclin H/MAT1 activity for screening and profiling applications, using ADP-Glo® as a detection reagent.
- Methodology: Chemiluminescent
- Supplied As: The CDK7 Assay Kit comes in a convenient 96-well format, with enough purified recombinant CDK7/Cyclin H/MAT1 enzyme, CDK substrate peptide, ATP and kinase assay buffer for 100 enzyme reactions.
- Unspsc Code: 41121811
- Unspsc Name: Laboratory microchemistry kits
- Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
- Product Type: Assay Kit
- Biosafety Level: Not applicable (BSL-1)
- Related Products: 40098, 79597, 79599, 79600, 78487
- Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
- Scientific Category: Kinase
- Instructions For Use: See assay kit datasheet for detailed protocol.