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FAP-HP245-25tests FAP-HP245-200tests

PE-Labeled Human FAP Protein, His Tag (Site-specific conjugation)

ACROBiosystems

DESCRIPTION

PE-Labeled Human FAP, His Tag (FAP-HP245) is produced via site-specific conjugation of PE to Human FAP, His Tag under optimal conditions with a proprietary technology. Human FAP, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 760 (Accession # Q12884-1).

DETAILS

  • Tag: N-10×His
  • Host: HEK293
  • Size: 25tests
  • Buffer: PBS, 0.5% BSA, pH7.4
  • Format: Powder
  • Storage: -20℃, aviod light
  • Category: Fluorescent labeled protein
  • Molecule: FAP
  • Accession: NP_004451.2
  • Conjugate: PE Labeled
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asla consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
  • Exp Region: Leu 26 - Asp 760
  • Swiss-prot: Q12884-1
  • Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 93.1 kDa.
  • Molecular Weight: 93.1 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html