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Lumi-Verse™ VEGFR2 (KDR) Kinase Assay Kit
BPS Bioscience
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DESCRIPTION:
The Lumi-Verse™ VEGFR2 (KDR) Kinase Assay Kit is designed to measure Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) tyrosine kinase activity for screening and profiling applications, using the highly sensitive ADP-Glo™ as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant VEGFR2 (KDR) kinase domain (amino acids 805-1356), kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
DETAILS
- Notes: Troubleshooting Guide: Visit bpsbioscience.com/assay-kits-faq for detailed troubleshooting instructions. For further questions, please email support@bpsbioscience.com.
- Uniprot: P35968
- Shiptemp: -80°C (dry ice)
- Synonyms: Fetal liver kinase 1 (FLK-1), Kinase insert domain receptor (KDR), Protein-tyrosine kinase receptor flk-1, FLK1, VEGFR2
- Warnings: Avoid freeze/thaw cycles
- Category: Kinase/Assay Kit
- Background: Vascular endothelial growth factor receptor 2 (VEGFR2), also known as Kinase insert Domain receptor (KDR), is a tyrosine kinase receptor for the growth factor VEGF. EGFR (epidermal growth factor receptor) overexpression is a common feature in many cancer types, such as breast and ovarian cancer. EGFR activation results in VEGF expression and signaling via VEGFR2, promoting angiogenesis and tumor progression. The inhibition of VEGFR2 via small molecules or antibodies, alone or in combination with inhibitors of EGFR, are promising therapeutic strategies for cancer therapy.
- Description: The Lumi-Verse™ VEGFR2 (KDR) Kinase Assay Kit is designed to measure Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) tyrosine kinase activity for screening and profiling applications, using the highly sensitive ADP-Glo™ as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant VEGFR2 (KDR) kinase domain (amino acids 805-1356), kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
- Methodology: Luminescent
- Unspsc Code: 41105332
- Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
- Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
- Product Type: Assay Kit
- Biosafety Level: Not applicable (BSL-1)
- Related Products: 40301, 40325, 79387
- Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
- Scientific Category: Kinase