ICS-M5259-100ug ICS-M5259-1mg
Mouse ICOS / CD278 (C137S, C138S) Protein, Fc Tag
ACROBiosystems
DESCRIPTION
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
DETAILS
- Tag: C-Fc
- Host: HEK293
- Size: 100ug
- Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
- Format: Powder
- Purity: 95%
- Source: Mouse ICOS (C137S, C138S) Protein, Fc Tag (ICS-M5259) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Leu 144 (Accession # Q9WVS0-1 (C137S, C138S)).
- Storage: -20℃
- Category: Immune Checkpoint Proteins
- Molecule: ICOS
- Accession: NP_059508.2 (C137S,C138S)
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Glu 21 - Leu 144
- Swiss-prot: Q9WVS0-1 (C137S, C138S)
- Package Size: 100ug*1
- Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 40.6 kDa
- Shipping Condition: RT
- Species Reactivity: Mouse
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html