mouse monoclonal IgM; CROT Antibody (H-1) is an IgM κ mouse monoclonal CROT antibody (also designated CROT antibody) that detects the CROT protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. CROT Antibody (H-1) is available as the non-conjugated anti-CROT antibody. CROT (carnitine O-octanoyltransferase), also called COT (carnitine octanoyl-transferase), is a member of the carnitine/choline acetyltransferase protein family, which also includes CAT, CPTI, CPTI-M and CPTII. Carnitine/choline acetyltransferase family members are essential for the β-oxidation of fatty acids. CROT localizes to peroxisomes and is highly expressed in liver, kidney and proximal intestinal epithelium. CROT plays a role in lipid metabolism, catalyzing the reversible conversion of acyl-CoAs to their corresponding carnitine esters—a crucial step in facilitating the transport of fatty acids out of peroxisomes to mitochondria, where they can be further degraded. With a preference for straight and branched medium-chain acyl-CoAs (C6-C10 chain length), CROT plays an important role in energy metabolism in eukaryotes. In addition, CROT activity can be inhibited by malonyl-CoA.