EIF4EBP1 Antibody(S111) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 1978
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: EIF4EBP1
Other Names: Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Availability: 2 weeks
Bio Background: EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Bio References: Fonseca,B.D., J. Biol. Chem. 282 (34), 24514-24524 (2007)Armengol,G., Cancer Res. 67 (16), 7551-7555 (2007)
Other Accession: NP_004086
Primary Accession: Q13541
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1981d was selected from the S111 region of human EIF4EBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.