mouse monoclonal IgG1; WAVE1 Antibody (E-2) is an IgG1 κ mouse monoclonal WAVE1 antibody (also designated WASP Family Member 1 antibody, SCAR1 antibody, WAVE1 antibody, Wiskott-Aldrich Syndrome Protein Family Member 1 antibody, Verprolin Homology Domain-Containing Protein 1 antibody, WASP Family Protein Member 1 antibody, WAS Protein Family Member 1 antibody, or Protein WAVE-1 antibody) that detects the WAVE1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. WAVE1 Antibody (E-2) is available as both the non-conjugated anti-WAVE1 antibody form, as well as multiple conjugated forms of anti-WAVE1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.