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17730

Scientist.com Supplier

Liproxstatin-1

Cayman Chemical

- Open Babel Depiction NH NH Cl HN N

DESCRIPTION

A ferroptosis inhibitor; inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in inducible Gpx4-/- MEFs at 50 nM; inhibits ferroptosis induced by the ferroptosis-inducing agents BSO, erastin, and (1S,3R)-RSL3 in a concentration-dependent manner in MEFs; inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells; increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice at 10 mg/kg; reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury; an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals

DETAILS

  • Inchi: InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Antioxidants||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
  • Smiles: ClC1=CC(CNC(C2(CCNCC2)N3)=NC4=C3C=CC=C4)=CC=C1
  • Inchikey: YAFQFNOUYXZVPZ-UHFFFAOYSA-N
  • Cas Number: 950455-15-9
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C19H21ClN4
  • Formula Weight: 340.9
  • Shelf Life Days: 730