PF-8380

DESCRIPTION:

An inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay); reverses leptin-induced MMP-13 expression in human OA chondrocytes at 10 µM; reduces LPA production by >95% following carrageenan-induced inflammation in rats at 30 mg/kg; inhibits autotaxin activity in human whole blood (IC50 = 101 nM)

DETAILS

Inchi: InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29)
Purity: ≥95%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation
Smiles: O=C(C1=CC(OC(N2)=O)=C2C=C1)CCN3CCN(C(OCC4=CC(Cl)=CC(Cl)=C4)=O)CC3
Inchikey: JMSUDQYHPSNBSN-UHFFFAOYSA-N
Cas Number: 1144035-53-9
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C22H21Cl2N3O5
Formula Weight: 478.3
Shelf Life Days: 1460