Phospho-mouse ERBB2(Y1197) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 13866
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: Erbb2
Other Names: Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu
Availability: 2 weeks
Bio Background: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Bio References: Cabodi, S., et al. FASEB J. 24(10):3796-3808(2010) Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010) Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010) Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010) Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010)
Other Accession: NP_001003817.1
Primary Accession: P70424
Targetspecificity: The synthetic peptide sequence is selected from aa 1190-1204 of MOUSE Erbb2