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GHR-H5257-50ug GHR-H5257-1mg

Human Growth Hormone R (GHR) Protein, Fc Tag

ACROBiosystems

DESCRIPTION

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

DETAILS

  • Tag: C-Fc
  • Host: HEK293
  • Size: 1mg
  • Buffer: PBS, pH7.4
  • Format: Powder
  • Purity: 95%
  • Source: Human GHR, Fc Tag (GHR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Tyr 264 (Accession # P10912).
  • Storage: -20℃
  • Category: Bio-Markers & CD Antigens
  • Molecule: Growth Hormone R
  • Accession: P10912
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Exp Region: Ala 27 - Tyr 264
  • Swiss-prot: P10912
  • Package Size: 500ug*2
  • Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 135-160 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 54.3 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html