Human Alpha-Synuclein Protein, Tag Free (MALS verified)

DESCRIPTION

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

DETAILS

Tag: Native
Host: E. coli
Size: 200ug
Buffer: 50 mM HEPES, 100 mM NaCl, pH7.5
Format: Liquid
Purity: 90%
Source: Human Alpha-Synuclein, Tag Free (ALN-H5214) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Storage: -70℃
Category: Other Recombinant Proteins
Molecule: Alpha-synuclein
Conjugate: Unconjugated
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Exp Region: Met 1 - Ala 140
Swiss-prot: P37840-1
Package Size: 200ug*1
Characteristics: This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 15-16 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 14.5 kDa
Shipping Condition: Dry ice
Species Reactivity: Human
Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html