Huntingtin Associated Protein 1 (HAP1) antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 9001
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: HAP1
Other Names: Huntingtin-associated protein 1, HAP-1, Neuroan 1, HAP1, HAP2, HLP1
Availability: 2 weeks
Bio Background: Huntington's disease is caused by the expansion of a glutamine repeat in the protein huntingtin. This glutamate repeat expansion disrupts normal protein-protein interactions with huntingtin. Human HAP1 (huntintin-associated protein) is a 75 kDa protein specifically expressed in human brain and binds more tightly to mutant huntingtin with the expanded glutamine repeat than to wild type huntingtin. HAP1 expression in Huntington's disease brains is reduced concomitant with decreased expression of huntingtin.
Bio References: Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Li, S.H., et al., J. Biol. Chem. 273(30):19220-19227 (1998).Li, X.J., et al., Nature 378(6555):398-402 (1995).Nasir, J., et al., Gene 254 (1-2), 181-187 (2000).
Other Accession: HAP1_HUMAN
Primary Accession: P54257
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP6118a was selected from the C-term region of human HAP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.