Biotinylated Human OX40 Ligand / TNFSF4 Protein, Fc,Avitag™, premium grade

DESCRIPTION

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

DETAILS

Tag: N-Avi & N-Fc
Host: HEK293
Size: 200ug
Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, PH7.5
Format: Powder
Purity: 90%
Source: Biotinylated Human OX40 Ligand Protein, Avitag,Fc Tag, premium grade (OXL-H82F5) is expressed from human 293 cells (HEK293). It contains AA Gln 51 - Leu 183 (Accession # P23510-1).
Storage: -20℃
Category: MABSol® Biotin Labeled Proteins
Molecule: OX40 Ligand
Conjugate: Biotin-labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Gln 51 - Leu 183
Swiss-prot: P23510-1
Package Size: 200ug*1
Characteristics: This protein carries an Avi tag (Avitag™) at the N-terminus, followed by a human IgG1 Fc tag. The protein has a calculated MW of 75.7 kDa. The protein migrates as ＞145 kDa under reducing (R) condition, and 135-235 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 0.01 EU per μg
Molecular Weight: 75.7 kDa
Shipping Condition: RT
Species Reactivity: Human
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