PTPN7 Antibody (S44) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5778
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PTPN7
Other Names: Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP, Protein-tyrosine phosphatase LC-PTP, PTPN7
Availability: 2 weeks
Bio Background: PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Bio References: Eswaran,J., Biochem. J. 395 (3), 483-491 (2006)Mustelin,T., J. Mol. Biol. 354 (1), 150-163 (2005)Pettiford,S.M., Leukemia 17 (2), 366-378 (2003)Kosaki,K., J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)
Primary Accession: P35236
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7599a was selected from the S44 region of human PTPN7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.