Human IgG1 Fc (C103S, M135Y, S137T, T139E) Protein, His Tag

DESCRIPTION

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Format: Powder
Purity: 90%
Source: Human IgG1 Fc (C103S, M135Y, S137T, T139E) Protein, His Tag (IG1-H52H5) is expressed from human 293 cells (HEK293). It contains AA Pro 100 - Lys 330 (Accession # P01857-1 (C103S, M135Y, S137T, T139E)).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: IgG1 Fc
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Pro 100 - Lys 330 (C103S, M135Y, S137T, T139E)
Swiss-prot: P01857-1 (C103S, M135Y, S137T, T139E)
Package Size: 200ug*5
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.8 kDa. The protein migrates as 33-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 27.8 kDa
Shipping Condition: RT
Species Reactivity: Human
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