Phospho-MYC(T358) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 4609
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MYC
Other Names: Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
Availability: 2 weeks
Bio Background: MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
Bio References: Qi, Y., et al., Nature 431(7009):712-717 (2004).Wilda, M., et al., Genes Chromosomes Cancer 41(2):178-182 (2004).Dom, et al., Oncogene 23(44):7378-7390 (2004).Pap, T., et al., Arthritis Rheum. 50(9):2794-2802 (2004).Ozawa, N., et al., Endocrinology 145(9):4244-4250 (2004).
Primary Accession: P01106
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3386a was selected from the region of human Phospho-MYC-T358. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.