Mouse Tbk1 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 56480
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: Tbk1
Other Names: Serine/threonine-protein kinase TBK1, T2K, TANK-binding kinase 1, Tbk1
Availability: 2 weeks
Bio Background: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.
Bio References: Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010)Watanabe, T., et al. J. Clin. Invest. 120(5):1645-1662(2010)Gabhann, J.N., et al. J. Immunol. 184(5):2314-2320(2010)Munoz, M.C., et al. J. Endocrinol. 201(2):185-197(2009)Miyahira, A.K., et al. J. Immunol. 182(4):2248-2257(2009)
Primary Accession: Q9WUN2