mouse monoclonal IgG1; MuRF1 Antibody (C-11) is an IgG1 κ mouse monoclonal MuRF1 antibody (also designated Tripartite motif containing 63 antibody, TRIM-63 antibody, RING zinc finger protein family member 28 antibody, RNF28 antibody, Muscle RING Finger 1 antibody, MURF1 antibody, MURF-1 antibody, E3 ubiquitin-protein ligase TRIM63 antibody, or skeletal muscle specific RING zinc finger protein family member antibody) that detects the MuRF1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. MuRF1 Antibody (C-11) is available as both the non-conjugated anti-MuRF1 antibody form, as well as multiple conjugated forms of anti-MuRF1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Muscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.