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AHE-H52H3-20ug AHE-H52H3-500ug

Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)

ACROBiosystems

DESCRIPTION

Human ACHE, His Tag (AHE-H52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 32 - Leu 614 (Accession # P22303-1).

DETAILS

  • Tag: C-10×His
  • Host: HEK293
  • Size: 20ug
  • Buffer: PBS, pH7.4
  • Format: Powder
  • Purity: 95%
  • Storage: -20℃
  • Category: Other Recombinant Proteins
  • Molecule: ACHE
  • Accession: NP_001289551.1
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine(ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. Acetylcholine deficit has been found in Alzheimer's disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.
  • Exp Region: Glu 32 - Leu 614
  • Swiss-prot: P22303-1
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 66.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 66.5 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html