SPAM1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 6677
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SPAM1
Other Names: Hyaluronidase PH-20, Hyal-PH20, Hyaluronoglucosaminidase PH-20, Sperm adhesion molecule 1, Sperm surface protein PH-20, SPAM1, HYAL3, PH20
Availability: 2 weeks
Bio Background: Hyaluronidase degrades hyaluronic acid, a major structuralproteoglycan found in extracellular matrices and basementmembranes. Six members of the hyaluronidase family are clusteredinto two tightly linked groups on chromosome 3p21.3 and 7q31.3.This gene was previously referred to as HYAL1 and HYA1 and hassince been assigned the official symbol SPAM1; another familymember on chromosome 3p21.3 has been assigned HYAL1. This geneencodes a GPI-anchored enzyme located on the human sperm surfaceand inner acrosomal membrane. This multifunctional protein is ahyaluronidase that enables sperm to penetrate through thehyaluronic acid-rich cumulus cell layer surrounding the oocyte, areceptor that plays a role in hyaluronic acid induced cellsignaling, and a receptor that is involved in sperm-zona pellucidaadhesion. Abnormal expression of this gene in tumors has implicatedthis protein in degradation of basement membranes leading to tumorinvasion and metastasis. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Bio References: Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Dunn, C.A., et al. BMC Genomics 6 (1), 47 (2005) :Evans, E.A., et al. Reprod. Biol. Endocrinol. 1, 54 (2003) :Cherr, G.N., et al. Matrix Biol. 20(8):515-525(2001)Csoka, A.B., et al. Matrix Biol. 20(8):499-508(2001)
Primary Accession: P38567