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SPR-131A SPR-130A SPR-131B SPR-130B +2

Mn SOD Protein

Stressmarq Biosciences


Rat Recombinant Mn SOD Protein


  • Nature: Recombinant
  • Purity: >90%
  • Target: Mn SOD
  • Category: Protein
  • Conjugate: His tag
  • References: 1. Adachi T., et al. (1992) Clin. Chim. Acta. 212: 89-102. 2. Barrister J.V., et al. (1987) Crit. Rev. Biochem. 22: 111-180. 3. Furukawa Y., and O'Halloran T. (2006) Antioxidants &Redo Signaling. 8 (No 5): 6. 4. Gao B., et al. (2003). Am J Physiol Lung Cell Mol Physiol. 284: L917-L925. 5. Hassan H.M. (1988). Free Radical Biol. Med. 5: 377-385. 6. Kurobe N., et al. (1990) Clinica Chimica Acta. 192: 171-180. 7. Ojika T., et al. (1991) Acta Histochem Cytochem. 24(50): 489-495. 8. Wispe J.R., et al. (1989) BBA. 994: 30-36.
  • Applications: WB | SDS-PAGE
  • Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
  • Protein Size: ~25 kDa
  • Purification: Affinity Purified
  • Concentration: Lot/batch specific. See included datasheet.
  • Protein Length: Partial
  • Research Areas: Cancer | Oxidative Stress | Cell Signaling | Protein Trafficking | Chaperone Proteins | Neuroscience | Neurodegeneration | ALS Disease
  • Storage Buffer: 50mM Tris/HCl pH7.7, 0.3M NaCl
  • Alternative Names: Manganese SOD Protein, IPO B Protein, Mn SOD Protein, SOD2 Protein
  • Cite This Product: Rat Recombinant Mn SOD Protein (StressMarq Biosciences, Canada, Cat # SPR-130A)
  • Expression System: E. coli
  • Species Full Name: Rat
  • Storage Temperature: -20ºC
  • Shipping Temperature: Blue Ice or 4ºC
  • Cellular Localization: Mitochondrion Matrix
  • Scientific Background: Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extracellular space(8). SOD3 can also be distinguished by its heparin-binding capacity (1).
  • Certificate of Analysis: This product has been certified >90% pure using SDS-PAGE analysis.