Peiminine

DESCRIPTION

An alkaloid with diverse biological activities; increases LC3B-II protein levels and induces cell death in HCT116 colorectal carcinoma cells in a concentration-dependent manner; reduces tumor growth in an HCT116 mouse xenograft model at 3 mg/kg every other day; has antitussive effects in a mouse cough model induced by ammonia liquor at3 mg/kg; reduces dermal and epidermal thickness, inhibits dermal infiltration of eosinophils and mast cells, and decreases serum levels of IgE, IL-4, and TNF-α in a mouse model of DNCB-induced atopic dermatitis at 5 mg/kg

DETAILS

Inchi: InChI=1S/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,25-,26+,27-/m0/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity
Smiles: C[C@H]1CC[C@@]2([H])[C@](O)(C)[C@@]3([H])CC[C@@]4([H])[C@]5([H])CC([C@]6([H])[C@@](CC[C@H](O)C6)(C)[C@@]5([H])C[C@@]4([H])[C@]3([H])CN2C1)=O
Inchikey: IQDIERHFZVCNRZ-YUYPDVIUSA-N
Cas Number: 18059-10-4
Formulation: A solid
Item Origin: Plant/Fritillaria thun-bergli
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C27H43NO3
Formula Weight: 429.6
Shelf Life Days: 1460