Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP)

DESCRIPTION

Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP) (SLS-H52P4) is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2) (Accession # Q9UPY5 (SLC7A11) & P08195 (SLC3A2)).

DETAILS

Host: HEK293
Size: 500ug
Buffer: PBS, Arginine, pH7.4
Format: Liquid
Storage: -70℃
Category: Bio-Markers & CD Antigens
Molecule: SLC7A11 & SLC3A2
Conjugate: Unconjugated
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 12 months under sterile conditions.
Background: Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell. System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.
Exp Region: Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2)
Swiss-prot: Q9UPY5 | P08195 | AF201927
Characteristics: This protein .
Endotoxin Level: 1.0 EU per μg
Shipping Condition: Dry ice
Species Reactivity: Human
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