Phospho-PIK3R1(Y556) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5295
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PIK3R1
Other Names: Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1, GRB1
Availability: 2 weeks
Bio Background: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This antibody is directed against an epitope in the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in the gene has been associated with insulin resistance.
Bio References: Kobayashi, H., et al., J. Biol. Chem. 279(8):6371-6379 (2004).Liu, H., et al., J. Cell Biol. 164(4):603-612 (2004).Sun, M., et al., J. Biol. Chem. 278(44):42992-43000 (2003).Khan, N.A., et al., J. Neurovirol. 9(6):584-593 (2003).Lee, H.Y., et al., J. Biol. Chem. 278(26):23630-23638 (2003).
Primary Accession: P27986
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3465a was selected from the region of human Phospho-PIK3R1-Y556. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.