FDPS Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 2224
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: FDPS
Other Names: Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Availability: 2 weeks
Bio Background: The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
Bio References: Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Nomura, N., et al., DNA Res. 1(1):27-35 (1994).Wilkin, D.J., et al., J. Biol. Chem. 265(8):4607-4614 (1990).Sheares, B.T., et al., Biochemistry 28(20):8129-8135 (1989).
Other Accession: FPPS_HUMAN
Primary Accession: P14324
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2418b was selected from the Center region of human FDPS . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.