RPA1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 6117
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RPA1
Other Names: Replication protein A 70 kDa DNA-binding subunit, RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein, Replication protein A 70 kDa DNA-binding subunit, N-terminally processed, RPA1, REPA1, RPA70
Availability: 2 weeks
Bio Background: RPA1 plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Bio References: Choi, J.H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13660-13665(2010)Locatelli, G.A., et al. Biochem. J. 429(3):573-582(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Guillem, V.M., et al. Am. J. Hematol. 85(7):482-486(2010)Oakley, G.G., et al. Front. Biosci. 15, 883-900 (2010) :
Primary Accession: P27694